Certified Gastroenterology Registered Nurse Practice Exam 2026 - Free CGRN Practice Questions and Study Guide

Celiac disease is a condition that can significantly disrupt the absorptive function of the duodenum. This autoimmune disorder occurs in genetically predisposed individuals and is triggered by the ingestion of gluten, a protein found in wheat, barley, and rye. When individuals with celiac disease consume gluten, their immune system responds by damaging the lining of the small intestine, particularly the villi in the duodenum. These villi are crucial for nutrient absorption; their destruction leads to malabsorption of essential nutrients, such as vitamins, minerals, and fats, resulting in various nutritional deficiencies and symptoms like diarrhea, weight loss, and abdominal discomfort.

In contrast, while conditions like cholecystitis, pancreatitis, and appendicitis can impact digestion and may cause abdominal discomfort, they do not primarily affect the absorptive function of the duodenum in the same direct manner as celiac disease. Cholecystitis relates to inflammation of the gallbladder and can influence bile production, while pancreatitis involves inflammation of the pancreas impacting digestive enzyme release. Appendicitis primarily involves inflammation of the appendix and does not directly affect nutrient absorption in the duodenum. Thus, the association between celiac disease and duodenal absorption issues makes it the